Evaluation of tumour vascularisation in two rat sarcoma models for studying isolated lung perfusion. Injection route determines the origin of tumour vessels.

Détails

ID Serval
serval:BIB_09C54F08A214
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evaluation of tumour vascularisation in two rat sarcoma models for studying isolated lung perfusion. Injection route determines the origin of tumour vessels.
Périodique
European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Auteur(s)
Pan Y., Krueger T., Tran N., Yan H., Ris H.B., McKee T.A.
ISSN
0014-312X (Print)
ISSN-L
0014-312X
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
37
Numéro
2
Pages
92-99
Langue
anglais
Notes
Publication types: In Vitro ; Journal Article
Publication Status: ppublish
Résumé
Isolated cytostatic lung perfusion (ILP) is an attractive technique allowing delivery of a high-dose of cytostatic agents to the lungs while limiting systemic toxicity. In developing a rat model of ILP, we have analysed the effect of the route of tumour cell injection on the source of tumour vessels. Pulmonary sarcomas were established by injecting a sarcoma cell suspension either by the intravenous (i.v.) route or directly into the lung parenchyma. Ink perfusion through either pulmonary artery (PA) or bronchial arteries (BA) was performed and the characteristics of the tumour deposits defined. i.v. and direct injection methods induced pulmonary sarcoma nodules, with similar histological features. The intraparenchymal injection of tumour cells resulted in more reliable and reproducible tumour growth and was associated with a longer survival of the animals. i.v. injected tumours developed a PA-derived vascular tree whereas directly injected tumours developed a BA-derived vasculature.
Mots-clé
Animals, Bronchial Arteries/pathology, Bronchial Arteries/physiopathology, Disease Models, Animal, Injections, Intravenous, Lung Neoplasms/blood supply, Lung Neoplasms/pathology, Male, Neoplasm Transplantation/methods, Neovascularization, Pathologic/physiopathology, Perfusion, Pulmonary Artery/pathology, Pulmonary Artery/physiopathology, Pulmonary Circulation, Rats, Rats, Inbred F344, Sarcoma/blood supply, Sarcoma/pathology, Trachea
Pubmed
Web of science
Création de la notice
29/01/2008 14:00
Dernière modification de la notice
20/08/2019 13:31
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