Influence of laminin or fibroblasts upon colony formation in the mouse by B16 melanoma cell spheroids: a morphometric analysis.

Détails

ID Serval
serval:BIB_0966926FE750
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Influence of laminin or fibroblasts upon colony formation in the mouse by B16 melanoma cell spheroids: a morphometric analysis.
Périodique
In Vivo (athens, Greece)
Auteur(s)
Coucke P., De Leval L., Leyh P., Bonjean K., Siwek B., Noel A., De Pauw-Gillet M.C., Paulus J.M., Bassleer R., Foidart J.M.
ISSN
0258-851X[print], 0258-851X[linking]
Statut éditorial
Publié
Date de publication
1992
Volume
6
Numéro
2
Pages
119-124
Langue
anglais
Résumé
By microscopical observation and using an original morphometric method, we analyzed on histological sections the rate of lung colony formation after the intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as aggregates. After the injection of B16 pure spheroids, superficial lung colonies were more numerous than internal lung colonies. After the injection of mixed spheroids (B16 + 3T3 fibroblasts), the size of colony sections was increased. Addition of laminin to pure or mixed spheroids decreased the size of colony sections but increased the number of internal lung colonies.
Mots-clé
3T3 Cells/physiology, Animals, Cell Communication, Cell Division, Culture Techniques/methods, Laminin/pharmacology, Lung Neoplasms/blood supply, Lung Neoplasms/pathology, Melanoma, Experimental/blood supply, Melanoma, Experimental/pathology, Mice, Neoplasm Invasiveness, Neoplasm Transplantation, Neovascularization, Pathologic, Tumor Cells, Cultured/drug effects, Tumor Cells, Cultured/pathology
Pubmed
Création de la notice
29/10/2010 7:59
Dernière modification de la notice
20/08/2019 12:31
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