Angiotensinergic innervation of the kidney: present knowledge and its significance.

Détails

ID Serval
serval:BIB_0959891ED30B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Angiotensinergic innervation of the kidney: present knowledge and its significance.
Périodique
Current Hypertension Reports
Auteur(s)
Bohlender J., Nussberger J., Imboden H.
ISSN
1534-3111 (Electronic)
ISSN-L
1522-6417
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
15
Numéro
1
Pages
10-16
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Intrarenal neurotransmission implies the co-release of neuropeptides at the neuro-effector junction with direct influence on parameters of kidney function. The presence of an angiotensin (Ang) II-containing phenotype in catecholaminergic postganglionic and sensory fibers of the kidney, based on immunocytological investigations, has only recently been reported. These angiotensinergic fibers display a distinct morphology and intrarenal distribution, suggesting anatomical and functional subspecialization linked to neuronal Ang II-expression. This review discusses the present knowledge concerning these fibers, and their significance for renal physiology and the pathogenesis of hypertension in light of established mechanisms. The data suggest a new role of Ang II as a co-transmitter stimulating renal target cells or modulating nerve traffic from or to the kidney. Neuronal Ang II is likely to be an independent source of intrarenal Ang II. Further physiological experimentation will have to explore the role of the angiotensinergic renal innervation and integrate it into existing concepts.
Pubmed
Web of science
Création de la notice
15/02/2013 12:37
Dernière modification de la notice
20/08/2019 12:31
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