Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study.

Détails

ID Serval
serval:BIB_091FFBF1EAAB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study.
Périodique
Thyroid
Auteur(s)
Kimura E.T., Kopp P., Zbaeren J., Asmis L.M., Ruchti C., Maciel R.M., Studer H.
ISSN
1050-7256 (Print)
ISSN-L
1050-7256
Statut éditorial
Publié
Date de publication
02/1999
Peer-reviewed
Oui
Volume
9
Numéro
2
Pages
119-125
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The various isoforms of transforming growth factor-beta (TGFbeta) are growth-inhibiting cytokines for cells of epithelial origin. In malignant thyroid tumors, several studies documented a high expression of TGFbeta in the majority of thyroid follicular cells suggesting a possible role as an inhibitor of cell proliferation. In contrast to this uniform pattern of TGFbeta expression in thyroid cancer, scarce and controversial data have been reported on the expression of TGFbeta in benign multinodular goiter. In the present study, we therefore analyzed the expression of TGFbeta1, TGFbeta2, and TGFbeta3 in normal thyroid tissue, multinodular goiters and papillary thyroid carcinomas by immunohistochemistry. In normal thyroid tissue, expression of the 3 TGFbeta isoforms was barely detectable. However, in the carcinomas, almost all epithelial cells displayed immunoreactivity for the three TGFbeta isoforms. In the nodules from multinodular goiters, all 3 isoforms were found to be expressed although the immunolocalization of the 3 proteins was highly variable. TGFbeta-immunostaining was found in scattered clusters of variable size and, its expression pattern was heterogenous among individual cells within single follicles. TGFbeta-positivity was present in spite of immunostaining for proliferating cell nuclear antigen (PCNA), a marker for actively proliferating cells. In conclusion, this study shows that thyroid carcinomas and benign tumors express the TGFbeta1, TGFbeta2, and TGFbeta3 isoforms. In contrast to the abundant and homogeneous expression in differentiated thyroid carcinomas, TGFbeta expression displays a highly variable interfollicular and intrafollicular pattern in multinodular goiters, suggesting an important role of TGFbeta isoforms in tumorigenesis of thyroid cells.
Mots-clé
Adenocarcinoma, Follicular/metabolism, Carcinoma/metabolism, Carcinoma, Papillary/metabolism, Gene Expression, Goiter, Nodular/metabolism, Immunohistochemistry, Proliferating Cell Nuclear Antigen/analysis, Thyroid Neoplasms/metabolism, Transforming Growth Factor beta/analysis, Transforming Growth Factor beta/genetics
Pubmed
Web of science
Création de la notice
30/12/2020 16:24
Dernière modification de la notice
31/12/2020 7:26
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