Shaping fission yeast with microtubules.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_08FCB80EEF26
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Shaping fission yeast with microtubules.
Périodique
Cold Spring Harbor Perspectives in Biology
Auteur⸱e⸱s
Chang F., Martin S.G.
ISSN
1943-0264 (Electronic)
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
1
Numéro
1
Pages
a001347
Langue
anglais
Résumé
For cell morphogenesis, the cell must establish distinct spatial domains at specified locations at the cell surface. Here, we review the molecular mechanisms of cell polarity in the fission yeast Schizosaccharomyces pombe. These are simple rod-shaped cells that form cortical domains at cell tips for cell growth and at the cell middle for cytokinesis. In both cases, microtubule-based systems help to shape the cell by breaking symmetry, providing endogenous spatial cues to position these sites. The plus ends of dynamic microtubules deliver polarity factors to the cell tips, leading to local activation of the GTPase cdc42p and the actin assembly machinery. Microtubule bundles contribute to positioning the division plane through the nucleus and the cytokinesis factor mid1p. Recent advances illustrate how the spatial and temporal regulation of cell polarization integrates many elements, including historical landmarks, positive and negative controls, and competition between pathways.
Mots-clé
Actins/chemistry, Cell Cycle, Cell Polarity, Cytokinesis, Cytoskeleton/metabolism, Gene Expression Regulation, Fungal, Green Fluorescent Proteins/chemistry, Microtubules/metabolism, Models, Biological, Mutation, Schizosaccharomyces/physiology, cdc42 GTP-Binding Protein/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/01/2010 18:51
Dernière modification de la notice
20/08/2019 13:31
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