Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_08B184DC5815
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.
Périodique
Cell reports
Auteur(s)
Panja D., Kenney J.W., D'Andrea L., Zalfa F., Vedeler A., Wibrand K., Fukunaga R., Bagni C., Proud C.G., Bramham C.R.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
20/11/2014
Volume
9
Numéro
4
Pages
1430-1445
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling. Surprisingly, this sustained activation maintains an otherwise labile signaling pathway from TrkB to MAP-kinase-interacting kinase (MNK). MNK activity promotes eIF4F translation initiation complex formation and protein synthesis in mechanistically distinct early and late stages. In early-stage translation, MNK triggers release of the CYFIP1/FMRP repressor complex from the 5'-mRNA cap. In late-stage translation, MNK regulates the canonical translational repressor 4E-BP2 in a synapse-compartment-specific manner. This late stage is coupled to MNK-dependent enhanced dendritic mRNA translation. We conclude that LTP consolidation in the dentate gyrus is mediated by sustained BDNF signaling to MNK and MNK-dependent regulation of translation in two functionally and mechanistically distinct stages.

Mots-clé
Animals, Brain-Derived Neurotrophic Factor/metabolism, Cytoskeletal Proteins/metabolism, Dentate Gyrus/metabolism, Enzyme Activation, Eukaryotic Initiation Factor-4F/metabolism, Eukaryotic Initiation Factors/metabolism, Extracellular Signal-Regulated MAP Kinases/metabolism, Fragile X Mental Retardation Protein/metabolism, Long-Term Potentiation, Mice, Knockout, Nerve Tissue Proteins/metabolism, Polyribosomes/metabolism, Protein Biosynthesis, Protein-Serine-Threonine Kinases/metabolism, Rats, Receptor, trkB/metabolism, Signal Transduction, Synapses/metabolism
Pubmed
Open Access
Oui
Création de la notice
06/03/2017 18:23
Dernière modification de la notice
20/08/2019 13:31
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