Treatment of craniopharyngioma in adults: systematic analysis of a 25-year experience.

Détails

ID Serval
serval:BIB_08A955487200
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Treatment of craniopharyngioma in adults: systematic analysis of a 25-year experience.
Périodique
Archives of medical research
Auteur⸱e⸱s
Lopez-Serna R., Gómez-Amador J.L., Barges-Coll J., Nathal-Vera E., Revuelta-Gutiérrez R., Alonso-Vanegas M., Ramos-Peek M., Portocarrero-Ortiz L.
ISSN
1873-5487 (Electronic)
ISSN-L
0188-4409
Statut éditorial
Publié
Date de publication
07/2012
Peer-reviewed
Oui
Volume
43
Numéro
5
Pages
347-355
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Craniopharyngioma is a rare and mostly benign epithelial tumor of the central nervous system, mostly affecting children. Considering that most of the published series of craniopharyngioma are based on pediatric populations, studies in adults gain importance based mainly on the reduced number of cases and the possible differences emerging from a mostly different histological type. We undertook this study to establish the pattern of presentation, morphological features and specific characteristics of craniopharyngioma in an adult Mexican population, as well as discussing the long-term outcome and how it may be influenced by surgical, anatomic and clinical factors.
A total of 153 adult patients (16 years or older) underwent transcranial and transsphenoidal surgery between January 1985 and December 2009, all with histological confirmation of craniopharyngioma. Hypothalamic involvement, surgical complications, rate of tumor resection and endocrinological outcome were evaluated.
Seventy nine males (51.6%) and 74 females (48.4%) were included. Mean age at diagnosis was 32.4 years (range: 16-77 years). Mean initial tumor volume was 28.44 mL (range: 0.18-100.44 mL). Partial or complete hypothalamic involvement (Samii Grades III, IV and V) was found in 90.2%. The overall rate of new endocrinopathies was 37.25% after surgery (95% CI = 33.9-41.2).
Gross total removal of craniopharyngiomas with large hypothalamic involvement was related to poor neuroendocrine outcome in adults. Partial removal should be indicated, associated with adjuvant therapy, in order to improve postoperative neuroendocrine status.
Mots-clé
Adolescent, Adult, Aged, Craniopharyngioma/blood, Craniopharyngioma/mortality, Craniopharyngioma/pathology, Craniopharyngioma/surgery, Female, Humans, Hypothalamo-Hypophyseal System/physiopathology, Kaplan-Meier Estimate, Male, Middle Aged, Multivariate Analysis, Pituitary Neoplasms/blood, Pituitary Neoplasms/mortality, Pituitary Neoplasms/pathology, Pituitary Neoplasms/surgery, Pituitary-Adrenal System/physiopathology, Retrospective Studies, Statistics, Nonparametric, Thyrotropin/blood, Thyroxine/blood, Triiodothyronine/blood, Tumor Burden, Young Adult
Pubmed
Web of science
Création de la notice
10/09/2019 16:51
Dernière modification de la notice
11/09/2019 5:26
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