Predicting positive food challenges in children sensitised to peanuts/tree nuts.

Détails

ID Serval
serval:BIB_086559E5CAF4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Predicting positive food challenges in children sensitised to peanuts/tree nuts.
Périodique
Pediatric Allergy and Immunology
Auteur⸱e⸱s
Ludman S., Ballabeni P., Eigennman P.A., Wassenberg J.
ISSN
1399-3038 (Electronic)
ISSN-L
0905-6157
Statut éditorial
Publié
Date de publication
2013
Volume
24
Numéro
3
Pages
276-281
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: original article
Résumé
BACKGROUND: Children with atopic diseases in early life are frequently found with positive IgE tests to peanuts/tree nuts without a history of previous ingestion. We aimed to identify risk factors for reactions to nuts at first introduction.
METHODS: A retrospective case-note and database analysis was performed. Recruitment criteria were: patients aged 3-16 yr who had a standardized food challenge to peanut and/or tree nuts due to sensitisation to the peanut/tree nut (positive spIgE or SPT) without previous consumption. A detailed assessment was performed of factors relating to food challenge outcome with univariate and multivariate logistic regression analysis.
RESULTS: There were 98 food challenges (47 peanut, 51 tree nut) with 29 positive, 67 negative and 2 inconclusive outcomes. A positive maternal history of allergy and a specific IgE >5 kU/l were strongly associated with a significantly increased risk of a positive food challenge (OR 3.73; 95% CI 1.31-10.59; p = 0.013 and OR 3.35; 95% CI 1.23-9.11; p = 0.007, respectively). Adjusting for age, a three year-old with these criteria has a 67% probability of a positive challenge. There was no significant association between types of peanut/tree nut, other food allergies, atopic conditions or severity of previous food reactions and positive challenges.
CONCLUSIONS: We have demonstrated an association between the presence of maternal atopic history and a specific IgE >5 kU/l, with a significant increase in the likelihood of a positive food challenge. Although requiring further prospective validation these easily identifiable components should be considered when deciding the need for a challenge.
Pubmed
Web of science
Création de la notice
31/05/2013 16:11
Dernière modification de la notice
20/08/2019 12:30
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