Microsatellites can be misleading: an empirical and simulation study.

Détails

Ressource 1Télécharger: BIB_08574EED056C.P001.pdf (127.04 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_08574EED056C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Microsatellites can be misleading: an empirical and simulation study.
Périodique
Evolution
Auteur⸱e⸱s
Balloux F., Brünner H., Lugon-Moulin N., Hausser J., Goudet J.
ISSN
0014-3820[print], 0014-3820[linking]
Statut éditorial
Publié
Date de publication
2000
Volume
54
Numéro
4
Pages
1414-1422
Langue
anglais
Résumé
It has been long recognized that highly polymorphic genetic markers can lead to underestimation of divergence between populations when migration is low. Microsatellite loci, which are characterized by extremely high mutation rates, are particularly likely to be affected. Here, we report genetic differentiation estimates in a contact zone between two chromosome races of the common shrew (Sorex araneus), based on 10 autosomal microsatellites, a newly developed Y-chromosome microsatellite, and mitochondrial DNA. These results are compared to previous data on proteins and karyotypes. Estimates of genetic differentiation based on F- and R-statistics are much lower for autosomal microsatellites than for all other genetic markers. We show by simulations that this discrepancy stems mainly from the high mutation rate of microsatellite markers for F-statistics and from deviations from a single-step mutation model for R-statistics. The sex-linked genetic markers show that all gene exchange between races is mediated by females. The absence of male-mediated gene flow most likely results from male hybrid sterility.
Mots-clé
Animals, Computer Simulation, DNA, Mitochondrial/genetics, Female, Genetic Markers, Genotype, Karyotyping, Male, Microsatellite Repeats, Models, Genetic, Models, Statistical, Mutation, Proteins/genetics, Shrews/classification, Shrews/genetics, Y Chromosome
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 17:10
Dernière modification de la notice
20/08/2019 12:30
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