Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets.

Détails

ID Serval
serval:BIB_080C86C65909
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets.
Périodique
Journal of child psychology and psychiatry, and allied disciplines
Auteur(s)
Postema M.C., Hoogman M., Ambrosino S., Asherson P., Banaschewski T., Bandeira C.E., Baranov A., Bau CHD, Baumeister S., Baur-Streubel R., Bellgrove M.A., Biederman J., Bralten J., Brandeis D., Brem S., Buitelaar J.K., Busatto G.F., Castellanos F.X., Cercignani M., Chaim-Avancini T.M., Chantiluke K.C., Christakou A., Coghill D., Conzelmann A., Cubillo A.I., Cupertino R.B., de Zeeuw P., Doyle A.E., Durston S., Earl E.A., Epstein J.N., Ethofer T., Fair D.A., Fallgatter A.J., Faraone S.V., Frodl T., Gabel M.C., Gogberashvili T., Grevet E.H., Haavik J., Harrison N.A., Hartman C.A., Heslenfeld D.J., Hoekstra P.J., Hohmann S., Høvik M.F., Jernigan T.L., Kardatzki B., Karkashadze G., Kelly C., Kohls G., Konrad K., Kuntsi J., Lazaro L., Lera-Miguel S., Lesch K.P., Louza M.R., Lundervold A.J., Malpas C.B., Mattos P., McCarthy H., Namazova-Baranova L., Nicolau R., Nigg J.T., Novotny S.E., Oberwelland Weiss E., O'Gorman Tuura R.L., Oosterlaan J., Oranje B., Paloyelis Y., Pauli P., Picon F.A., Plessen K.J., Ramos-Quiroga J.A., Reif A., Reneman L., Rosa PGP, Rubia K., Schrantee A., Schweren LJS, Seitz J., Shaw P., Silk T.J., Skokauskas N., Soliva Vila J.C., Stevens M.C., Sudre G., Tamm L., Tovar-Moll F., van Erp TGM, Vance A., Vilarroya O., Vives-Gilabert Y., von Polier G.G., Walitza S., Yoncheva Y.N., Zanetti M.V., Ziegler G.C., Glahn D.C., Jahanshad N., Medland S.E., Thompson P.M., Fisher S.E., Franke B., Francks C.
Collaborateur(s)
ENIGMA ADHD Working Group
ISSN
1469-7610 (Electronic)
ISSN-L
0021-9630
Statut éditorial
Publié
Date de publication
10/2021
Peer-reviewed
Oui
Volume
62
Numéro
10
Pages
1202-1219
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.
We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.
There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing.
Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
Mots-clé
Attention-deficit, brain asymmetry, brain laterality, hyperactivity disorder, large-scale data, structural MRI
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/03/2021 10:57
Dernière modification de la notice
23/10/2021 5:38
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