Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.

Détails

ID Serval
serval:BIB_07CE97F4A6F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.
Périodique
Journal of Immunology
Auteur⸱e⸱s
Bessa J., Jegerlehner A., Hinton H.J., Pumpens P., Saudan P., Schneider P., Bachmann M.F.
ISSN
1550-6606[electronic], 0022-1767[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
183
Numéro
6
Pages
3788-3799
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The mechanisms regulating systemic and mucosal IgA responses in the respiratory tract are incompletely understood. Using virus-like particles loaded with single-stranded RNA as a ligand for TLR7, we found that systemic vs mucosal IgA responses in mice were differently regulated. Systemic IgA responses following s.c. immunization were T cell independent and did not require TACI or TGFbeta, whereas mucosal IgA production was dependent on Th cells, TACI, and TGFbeta. Strikingly, both responses required TLR7 signaling, but systemic IgA depended upon TLR7 signaling directly to B cells whereas mucosal IgA required TLR7 signaling to lung dendritic cells and alveolar macrophages. Our data show that IgA switching is controlled differently according to the cell type receiving TLR signals. This knowledge should facilitate the development of IgA-inducing vaccines.
Mots-clé
Animals, Dendritic Cells/immunology, Immunoglobulin A/biosynthesis, Lung/immunology, Macrophages, Alveolar/immunology, Membrane Glycoproteins, Mice, Mice, Knockout, Mucous Membrane/immunology, RNA/immunology, T-Lymphocytes, Helper-Inducer, Toll-Like Receptor 7, Transforming Growth Factor beta, Transmembrane Activator and CAML Interactor Protein
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/11/2009 12:46
Dernière modification de la notice
20/08/2019 12:30
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