Unequal genetic redundancies in Arabidopsis--a neglected phenomenon?

Détails

ID Serval
serval:BIB_07B02D0B19F8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Unequal genetic redundancies in Arabidopsis--a neglected phenomenon?
Périodique
Trends in Plant Science
Auteur(s)
Briggs  G. C., Osmont  K. S., Shindo  C., Sibout  R., Hardtke  C. S.
ISSN
1360-1385 (Print)
Statut éditorial
Publié
Date de publication
10/2006
Volume
11
Numéro
10
Pages
492-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Résumé
Genetic redundancy is a common phenomenon in Arabidopsis and is thought to be responsible for the absence of phenotypes in the majority of single loss-of-function mutants. In this review, we highlight an increasing number of examples in which redundancy between homologous genes is limited or absent despite functional equivalence of the respective proteins. In particular, we focus on cases of unequal redundancy, where the absence of a mutant phenotype in loss-of-function mutants of one gene contrasts with a strong phenotype in mutants of its homolog. In the double mutants, this phenotype is strongly enhanced. Possible explanations for such scenarios are discussed. We propose that the study of unequally redundant gene pairs offers a unique opportunity to understand global patterns of functional genome evolution.
Mots-clé
Arabidopsis/*genetics/growth & development Arabidopsis Proteins/genetics/physiology *Evolution, Molecular Gene Duplication Gene Expression Regulation, Plant *Models, Genetic Mutation Phenotype Sequence Homology, Nucleic Acid
Pubmed
Web of science
Création de la notice
24/01/2008 20:51
Dernière modification de la notice
20/08/2019 13:30
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