Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular Ca<sup>2+</sup> Handling.

Détails

ID Serval
serval:BIB_07AD0AB346AF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular Ca<sup>2+</sup> Handling.
Périodique
Cold Spring Harbor perspectives in medicine
Auteur(s)
Cheng A.J., Place N., Westerblad H.
ISSN
2157-1422 (Electronic)
ISSN-L
2157-1422
Statut éditorial
Publié
Date de publication
01/02/2018
Peer-reviewed
Oui
Volume
8
Numéro
2
Pages
NA
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Résumé
The contractile function of skeletal muscle declines during intense or prolonged physical exercise, that is, fatigue develops. Skeletal muscle fibers fatigue acutely during highly intense exercise when they have to rely on anaerobic metabolism. Early stages of fatigue involve impaired myofibrillar function, whereas decreased Ca <sup>2+</sup> release from the sarcoplasmic reticulum (SR) becomes more important in later stages. SR Ca <sup>2+</sup> release can also become reduced with more prolonged, lower intensity exercise, and it is then related to glycogen depletion. Increased reactive oxygen/nitrogen species can cause long-lasting impairments in SR Ca <sup>2+</sup> release resulting in a prolonged force depression after exercise. In this article, we discuss molecular and cellular mechanisms of the above fatigue-induced changes, with special focus on multiple mechanisms to decrease SR Ca <sup>2+</sup> release to avoid energy depletion and preserve muscle fiber integrity. We also discuss fatigue-related effects of exercise-induced Ca <sup>2+</sup> fluxes over the sarcolemma and between the cytoplasm and mitochondria.
Mots-clé
Acidosis, Animals, Calcium/metabolism, Exercise/physiology, Humans, Motor Neurons/metabolism, Muscle Contraction/physiology, Muscle Fatigue/physiology, Muscle, Skeletal/physiology, Reactive Oxygen Species/metabolism, Refractory Period, Electrophysiological
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/04/2017 16:03
Dernière modification de la notice
20/08/2019 12:30
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