Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

Détails

ID Serval
serval:BIB_0799C114A94C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats
Périodique
Nature
Auteur(s)
Hilbert  P., Lindpaintner  K., Beckmann  J. S., Serikawa  T., Soubrier  F., Dubay  C., Cartwright  P., De Gouyon  B., Julier  C., Takahasi  S., Vincent  M., Ganten  D., Georges  M., Lathrop  G.M.
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
10/1991
Volume
353
Numéro
6344
Pages
521-9
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Oct 10
Résumé
The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.
Mots-clé
Animals Base Sequence Chromosome Mapping Hypertension/*genetics Linkage (Genetics) Molecular Sequence Data Peptidyl-Dipeptidase A/genetics Polymerase Chain Reaction Rats Rats, Inbred SHR/genetics Rats, Inbred WKY/genetics Receptors, Cell Surface/genetics Receptors, Nerve Growth Factor Receptors, Somatotropin/genetics X Chromosome
Pubmed
Web of science
Création de la notice
25/01/2008 17:17
Dernière modification de la notice
20/08/2019 13:29
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