Acute abdominal pain (AAP) represents the 9th most common complaint in general practice. The etiologies are multiple: a third are non-specific, but around 10% require hospital treatment. An accurate history enables a correct diagnosis in 76% of cases, and abdominal palpation can detect a possible surgical abdomen. This article summarizes the intra- and extra-abdominal causes of AAP, the diagnostic strategies, and the most appropriate complementary examinations. It lists the most common causes in general practice, as well as their management and reviews the warning signs not to be missed.