Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network
Détails
ID Serval
serval:BIB_0648AC389011
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network
Périodique
International Journal of Radiation Oncology, Biology, Physics
ISSN
0360-3016
Statut éditorial
Publié
Date de publication
09/2006
Peer-reviewed
Oui
Volume
66
Numéro
1
Pages
179-86
Notes
Journal Article
Multicenter Study --- Old month value: Sep 1
Multicenter Study --- Old month value: Sep 1
Résumé
PURPOSE: The aim of this study was to assess the outcome in patients with cerebellar glioblastoma (GBM) treated in 15 institutions of the Rare Cancer Network. METHODS AND MATERIALS: Data from a series of 45 adult patients with cerebellar GBM were collected in a retrospective multicenter study. Median age was 50.3 years. Brainstem invasion was observed in 9 (20%) patients. Radiotherapy (RT) was administered to 36 patients (with concomitant chemotherapy, 7 patients). Adjuvant chemotherapy after RT was administered in 8 patients. Median RT dose was 59.4 Gy. Median follow-up was 7.2 months (range, 3.4-39.0). RESULTS: The 1-year and 2-year actuarial overall survival rate was 37.8% and 14.7%, respectively, and was significantly influenced by salvage treatment (p = 0.048), tumor volume (p = 0.044), extent of neurosurgical resection (p = 0.019), brainstem invasion (p = 0.0013), additional treatment after surgery (p < 0.001), and completion of the initial treatment (p < 0.001) on univariate analysis. All patients experienced local progression: 8 and 22 had progression with and without a distant failure, respectively. The 1- and 2-year actuarial progression free survival was 25% and 10.7%, respectively, and was significantly influenced by brainstem invasion (p = 0.002), additional treatment after surgery (p = 0.0016), and completion of the initial treatment (p < 0.001). On multivariate analysis, survival was negatively influenced by the extent of surgery (p = 0.03) and brainstem invasion (p = 0.02). CONCLUSIONS: In this multicenter retrospective study, the observed pattern of failure was local in all cases, but approximately 1 patient of 4 presented with an extracerebellar component. Brainstem invasion was observed in a substantial number of patients and was an adverse prognostic factor.
Mots-clé
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Cerebellar Neoplasms/drug therapy/mortality/*radiotherapy
Combined Modality Therapy/methods
Disease Progression
Female
Glioblastoma/drug therapy/mortality/*radiotherapy
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Rare Diseases/drug therapy/mortality/*radiotherapy
Retrospective Studies
Survival Rate
Treatment Outcome
Pubmed
Web of science
Création de la notice
24/01/2008 18:16
Dernière modification de la notice
20/08/2019 13:28