A novel proangiogenic B cell subset is increased in cancer and chronic inflammation.

Détails

Ressource 1Télécharger: 32426497_BIB_060EB45A34E7.pdf (1068.67 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_060EB45A34E7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A novel proangiogenic B cell subset is increased in cancer and chronic inflammation.
Périodique
Science advances
Auteur⸱e⸱s
van de Veen W., Globinska A., Jansen K., Straumann A., Kubo T., Verschoor D., Wirz O.F., Castro-Giner F., Tan G., Rückert B., Ochsner U., Herrmann M., Stanić B., van Splunter M., Huntjens D., Wallimann A., Fonseca Guevara R.J., Spits H., Ignatova D., Chang Y.T., Fassnacht C., Guenova E., Flatz L., Akdis C.A., Akdis M.
ISSN
2375-2548 (Electronic)
ISSN-L
2375-2548
Statut éditorial
Publié
Date de publication
05/2020
Peer-reviewed
Oui
Volume
6
Numéro
20
Pages
eaaz3559
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
B cells contribute to immune responses through the production of immunoglobulins, antigen presentation, and cytokine production. Several B cell subsets with distinct functions and polarized cytokine profiles have been reported. In this study, we used transcriptomics analysis of immortalized B cell clones to identify an IgG4 <sup>+</sup> B cell subset with a unique function. These B cells are characterized by simultaneous expression of proangiogenic cytokines including VEGF, CYR61, ADM, FGF2, PDGFA, and MDK. Consequently, supernatants from these clones efficiently promote endothelial cell tube formation. We identified CD49b and CD73 as surface markers identifying proangiogenic B cells. Circulating CD49b <sup>+</sup> CD73 <sup>+</sup> B cells showed significantly increased frequency in patients with melanoma and eosinophilic esophagitis (EoE), two diseases associated with angiogenesis. In addition, tissue-infiltrating IgG4 <sup>+</sup> CD49b <sup>+</sup> CD73 <sup>+</sup> B cells expressing proangiogenic cytokines were detected in patients with EoE and melanoma. Our results demonstrate a previously unidentified proangiogenic B cell subset characterized by expression of CD49b, CD73, and proangiogenic cytokines.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2020 19:16
Dernière modification de la notice
15/01/2021 7:08
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