Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse.

Détails

ID Serval
serval:BIB_05F1B2083BF4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse.
Périodique
Nature Neuroscience
Auteur⸱e⸱s
Meye F.J., Soiza-Reilly M., Smit T., Diana M.A., Schwarz M.K., Mameli M.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
19
Numéro
8
Pages
1019-1024
Langue
anglais
Résumé
Cocaine withdrawal produces aversive states and vulnerability to relapse, hallmarks of addiction. The lateral habenula (LHb) encodes negative stimuli and contributes to aversive withdrawal symptoms. However, it remains unclear which inputs to LHb promote this and what the consequences are for relapse susceptibility. We report, using rabies-based retrolabeling and optogenetic mapping, that the entopeduncular nucleus (EPN, the mouse equivalent of the globus pallidus interna) projects to an LHb neuronal subset innervating aversion-encoding midbrain GABA neurons. EPN-to-LHb excitatory signaling is limited by GABAergic cotransmission. This inhibitory component decreases during cocaine withdrawal as a result of reduced presynaptic vesicular GABA transporter (VGAT). This shifts the EPN-to-LHb GABA/glutamate balance, disinhibiting EPN-driven LHb activity. Selective virally mediated VGAT overexpression at EPN-to-LHb terminals during withdrawal normalizes GABAergic neurotransmission. This intervention rescues cocaine-evoked aversive states and prevents stress-induced reinstatement, used to model relapse. This identifies diminished inhibitory transmission at EPN-to-LHb GABA/glutamate synapses as a mechanism contributing to the relapsing feature of addictive behavior.

Pubmed
Web of science
Création de la notice
31/01/2017 12:13
Dernière modification de la notice
20/08/2019 13:28
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