Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption.

Détails

ID Serval
serval:BIB_05E8E7DEABCF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption.
Périodique
Liver International : Official Journal of the International Association For the Study of the Liver
Auteur⸱e⸱s
Nollevaux M.C., Guiot Y., Horsmans Y., Leclercq I., Rahier J., Geubel A.P., Sempoux C.
ISSN
1478-3223 (Print)
ISSN-L
1478-3223
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
26
Numéro
2
Pages
182-186
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
UNLABELLED: Hypervitaminosis A-related liver toxicity may be severe and may even lead to cirrhosis. In the normal liver, vitamin A is stored in hepatic stellate cells (HSC), which are prone to becoming activated and acquiring a myofibroblast-like phenotype, producing large amounts of extracellular matrix.
AIMS: In order to assess the relationship between vitamin A intake, HSC activation and fibrosis, we studied nine liver biopsies from patients belonging to a well-characterized series of 41 patients with vitamin A hepatotoxicity.
METHODS: Fibrosis was underlined by Sirius-red staining, whereas activated HSC were immunohistochemically identified using an antibody against alpha smooth muscle actin. The volume density (Vv) of sinusoidal and total fibrosis and of sinusoidal and total activated HSC was quantified by the point-counting method.
RESULTS: Morphology ranged from HSC hypertrophy and hyperplasia as the sole features to severe architectural distortion. There was a significant positive correlation between Vv of perisinusoidal fibrosis and the daily consumption of vitamin A (P=0.004).
CONCLUSION: The close correlation between the severity of perisinusoidal fibrosis and the daily dose of the retinol intake suggests the existence of a dose-effect relationship.
Mots-clé
Actins/metabolism, Adult, Aged, Biomarkers/metabolism, Cell Enlargement/drug effects, Female, Humans, Hyperplasia/chemically induced, Hyperplasia/pathology, Hypervitaminosis A/chemically induced, Hypervitaminosis A/pathology, Immunohistochemistry, Kupffer Cells/drug effects, Kupffer Cells/metabolism, Liver/drug effects, Liver/metabolism, Liver Cirrhosis/chemically induced, Liver Cirrhosis/pathology, Male, Middle Aged, Vitamin A/adverse effects
Pubmed
Web of science
Création de la notice
20/10/2016 16:14
Dernière modification de la notice
20/08/2019 12:27
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