Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_05BAF0399093
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms.
Périodique
Frontiers in microbiology
Auteur(s)
Bibert S., Bratschi M.W., Aboagye S.Y., Collinet E., Scherr N., Yeboah-Manu D., Beuret C., Pluschke G., Bochud P.Y.
ISSN
1664-302X (Print)
ISSN-L
1664-302X
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
8
Pages
1903
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Otherwise, bacterial multiplication leads to in higher concentrations of mycolactone, with formation of necrotizing lesions that are no more accessible to immune cells. By typing a cohort of 96 Ghanaian BU patients and 384 endemic controls without BU, we show an association between BU and single nucleotide polymorphisms (SNPs) in iNOS (rs9282799) and IFNG (rs2069705). Both polymorphisms influence promoter activity in vitro. A previously reported SNP in SLC11A1 (NRAMP, rs17235409) tended to be associated with BU. Altogether, these data reflect the importance of IFNG signaling in early defense against M. ulcerans infection.

Mots-clé
Buruli ulcer, Mycobacterium ulcerans, immunogenetics, infectious diseases, single nucleotide polymorphism
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/10/2017 16:38
Dernière modification de la notice
20/08/2019 12:27
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