Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation.

Détails

ID Serval
serval:BIB_056BA5310320
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur⸱e⸱s
Willecke M., Hamaratoglu F., Sansores-Garcia L., Tao C., Halder G.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2008
Volume
105
Numéro
39
Pages
14897-14902
Langue
anglais
Résumé
The conserved Hippo tumor suppressor pathway is a key signaling pathway that controls organ size in Drosophila. To date a signal transduction cascade from the Cadherin Fat at the plasma membrane into the nucleus has been discovered. However, how the Hippo pathway is regulated by extracellular signals is poorly understood. Fat not only regulates growth but also planar cell polarity, for which it interacts with the Dachsous (Ds) Cadherin, and Four-jointed (Fj), a transmembrane kinase that modulates the interaction between Ds and Fat. Ds and Fj are expressed in gradients and manipulation of their expression causes abnormal growth. However, how Ds and Fj regulate growth and whether they act through the Hippo pathway is not known. Here, we report that Ds and Fj regulate Hippo signaling to control growth. Interestingly, we found that Ds/Fj regulate the Hippo pathway through a remarkable logic. Induction of Hippo target genes is not proportional to the amount of Ds or Fj presented to a cell, as would be expected if Ds and Fj acted as traditional ligands. Rather, Hippo target genes are up-regulated when neighboring cells express different amounts of Ds or Fj. Consistent with a model that differences in Ds/Fj levels between cells regulate the Hippo pathway, we found that artificial Ds/Fj boundaries induce extra cell proliferation, whereas flattening the endogenous Ds and Fj gradients results in growth defects. The Ds/Fj signaling system thus defines a cell-to-cell signaling mechanism that regulates the Hippo pathway, thereby contributing to the control of organ size.
Mots-clé
Animals, Cadherins/metabolism, Cell Membrane/metabolism, Cell Proliferation, Drosophila Proteins/metabolism, Drosophila melanogaster/cytology, Drosophila melanogaster/genetics, Gene Expression Regulation, Developmental, Intracellular Signaling Peptides and Proteins/metabolism, Membrane Glycoproteins/metabolism, Membrane Proteins/metabolism, Protein-Serine-Threonine Kinases/metabolism, Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/02/2014 16:39
Dernière modification de la notice
20/08/2019 12:27
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