Haemodynamic characterisation and heart catheterisation complications in children with pulmonary hypertension: Insights from the Global TOPP Registry (tracking outcomes and practice in paediatric pulmonary hypertension).

Détails

ID Serval
serval:BIB_056B93134C5D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
Haemodynamic characterisation and heart catheterisation complications in children with pulmonary hypertension: Insights from the Global TOPP Registry (tracking outcomes and practice in paediatric pulmonary hypertension).
Périodique
International journal of cardiology
Auteur⸱e⸱s
Beghetti M., Schulze-Neick I., Berger R.M., Ivy D.D., Bonnet D., Weintraub R.G., Saji T., Yung D., Mallory G.B., Geiger R., Berger J.T., Barst R.J., Humpl T.
Collaborateur⸱rice⸱s
TOPP Investigators
Contributeur⸱rice⸱s
Mattos S., Jing Z.C., Han Z.Y., Sondergaard L., Jensen T., Levy M., Mebus S., Apitz Ch, Szatmari A., Ablonczy L., Milanesi O., Favero V., Pulido T., De La Garza P., Douwes J.M., Brun H., Moll L., Michalak K., Kawalec W., Zuk M., Fasnacht Boillat M., Olgunturk R., Serdar Kula S., Alehan D., Day R.W., Austin E., Moore D.J., Atz A.M., Feinstein J.A.
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Statut éditorial
Publié
Date de publication
15/01/2016
Peer-reviewed
Oui
Volume
203
Pages
325-330
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The TOPP Registry has been designed to provide epidemiologic, diagnostic, clinical, and outcome data on children with pulmonary hypertension (PH) confirmed by heart catheterisation (HC). This study aims to identify important characteristics of the haemodynamic profile at diagnosis and HC complications of paediatric patients presenting with PH.
HC data sets underwent a blinded review for confirmation of PH (defined as mean pulmonary arterial pressure ≥ 25 mmHg, pulmonary capillary wedge pressure ≤ 12 mmHg and pulmonary vascular resistance index [PVRI] of >3 WU × m(2)). Of 568 patients enrolled, 472 who fulfilled the inclusion criteria and had sufficient data from HC were analysed. A total of 908 diagnostic and follow-up HCs were performed and complications occurred in 5.9% of all HCs including five (0.6%) deaths. General anaesthesia (GA) was used in 53%, and conscious sedation in 47%. Complications at diagnosis were more likely to occur if GA was used (p=0.04) and with higher functional class (p=0.02). Mean cardiac index (CI) was within normal limits at diagnosis when analysed for the entire group (3.7 L/min/m(2); 95% confidence interval 3.4-4.1), as was right atrial pressure despite a severely increased PVRI (16.6 WU × m(2,) 95% confidence interval 15.6-17.76). However, 24% of the patients had a CI of <2.5L/min/m(2) at diagnosis. A progressive increase in PVRI and decrease in CI was observed with age (p<0.001).
In TOPP, haemodynamic assessment was remarkable for preserved CI in the majority of patients despite severely elevated PVRI. HC-related complication incidence was 5.9%, and was associated with GA and higher functional class.
Mots-clé
Adolescent, Cardiac Catheterization/adverse effects, Child, Child, Preschool, Female, Follow-Up Studies, Global Health, Hemodynamics/physiology, Humans, Hypertension, Pulmonary/diagnosis, Hypertension, Pulmonary/physiopathology, Infant, Male, Outcome Assessment (Health Care), Prospective Studies, Pulmonary Artery/injuries, Pulmonary Artery/physiopathology, Registries, Risk Assessment/methods, Time Factors, Catheterisation, Congenital, Heart defects, Hypertension, Paediatrics, Pulmonary
Pubmed
Web of science
Création de la notice
14/01/2019 9:39
Dernière modification de la notice
11/10/2019 5:26
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