Mechanisms of inflammation in gout.

Détails

Ressource 1Télécharger: BIB_05680BF51A16.P001.pdf (545.66 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_05680BF51A16
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Mechanisms of inflammation in gout.
Périodique
Arthritis Research and Therapy
Auteur⸱e⸱s
Busso N., So A.
ISSN
1478-6362[electronic], 1478-6354[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
12
Numéro
2
Pages
206
Langue
anglais
Résumé
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.
Mots-clé
Acute Disease, Animals, Carrier Proteins/immunology, Chemotaxis, Leukocyte/immunology, Crystallization, Disease Models, Animal, Gout/immunology, Gout/pathology, Humans, Inflammation/immunology, Inflammation/pathology, Interleukin-1beta/secretion, Leukocytes/immunology, Leukocytes/pathology, Phagocytosis, Uric Acid/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/08/2010 14:55
Dernière modification de la notice
20/08/2019 12:27
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