Effect of Micafungin (FK463) on Candida albicans adherence to epithelial cells

Détails

ID Serval
serval:BIB_053F91D84021
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of Micafungin (FK463) on Candida albicans adherence to epithelial cells
Périodique
Chemotherapy
Auteur⸱e⸱s
Borg-von Zepelin  M., Zaschke  K., Gross  U., Monod  M., Muller  F. M.
ISSN
0009-3157 (Print)
Statut éditorial
Publié
Date de publication
07/2002
Volume
48
Numéro
3
Pages
148-53
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
BACKGROUND: Adherence is considered a major virulence trait of Candida albicans. FK463 is a new investigational intravenous antifungal of the 'candin family' with potent in vitro and in vivo activity against Candida spp. OBJECTIVE: The aim of the present study was to investigate the effect of Micafungin (FK463) on Candida adherence to epithelial cells of azole-sensitive and azole-resistant C. albicans isolates. METHODS: An in vitro assay using microtest plate technology and fluorescence measurement was developed to compare the adherence of C. albicans SC5314 and of paired C. albicans isolates to epithelial cells in the presence and in the absence of FK463. RESULTS: FK463 showed a marked inhibitory effect on the adherence of C. albicans SC5314. The addition of FK463 reduced the adherence of C. albicans SC5314 to 90% of the value of control without drug. A dose-dependent adherence inhibition was observed with FK463 in the range of 10-0.015 microg ml(-1). The comparison of paired C. albicans isolates, either a fluconazole-susceptible and a fluconazole-resistant isolate of one patient, revealed no significant difference in the adherence behavior between azole-susceptible and azole-resistant. CONCLUSION: Micafungin (FK463) has the capacity to reduce adherence of C. albicans azole-susceptible and azole-resistant strains to epithelial cells.
Mots-clé
Azoles/pharmacology Candida albicans/*drug effects/pathogenicity/physiology Cell Adhesion/drug effects Cell Communication/*drug effects Drug Resistance Epithelial Cells/drug effects/physiology Lipoproteins/*pharmacology Peptides, Cyclic/*pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 16:47
Dernière modification de la notice
20/08/2019 12:27
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