Non-Coding Transcript Heterogeneity in Mesothelioma: Insights from Asbestos-Exposed Mice.

Détails

ID Serval
serval:BIB_053DBA53C57C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Non-Coding Transcript Heterogeneity in Mesothelioma: Insights from Asbestos-Exposed Mice.
Périodique
International journal of molecular sciences
Auteur⸱e⸱s
Felley-Bosco E., Rehrauer H.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Statut éditorial
Publié
Date de publication
11/04/2018
Peer-reviewed
Oui
Volume
19
Numéro
4
Pages
E1163
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Mesothelioma is an aggressive, rapidly fatal cancer and a better understanding of its molecular heterogeneity may help with making more efficient therapeutic strategies. Non-coding RNAs represent a larger part of the transcriptome but their contribution to diseases is not fully understood yet. We used recently obtained RNA-seq data from asbestos-exposed mice and performed data mining of publicly available datasets in order to evaluate how non-coding RNA contribute to mesothelioma heterogeneity. Nine non-coding RNAs are specifically elevated in mesothelioma tumors and contribute to human mesothelioma heterogeneity. Because some of them have known oncogenic properties, this study supports the concept of non-coding RNAs as cancer progenitor genes.
Mots-clé
long-non-coding RNA, mesothelioma heterogeneity, non-coding RNA
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/08/2018 14:48
Dernière modification de la notice
20/08/2019 12:27
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