An in vivo study of the orientation-dependent and independent components of transverse relaxation rates in white matter.

Détails

ID Serval
serval:BIB_053492BA1137
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
An in vivo study of the orientation-dependent and independent components of transverse relaxation rates in white matter.
Périodique
NMR in biomedicine
Auteur⸱e⸱s
Gil R., Khabipova D., Zwiers M., Hilbert T., Kober T., Marques J.P.
ISSN
1099-1492 (Electronic)
ISSN-L
0952-3480
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
29
Numéro
12
Pages
1780-1790
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Diffusion-weighted imaging (DWI) provides information that allows the estimation of white-matter (WM) fibre orientation and distribution, but it does not provide information about myelin density, fibre concentration or fibre size within each voxel. On the other hand, quantitative relaxation contrasts (like the apparent transverse relaxation, R2∗) offer iron and myelin-related contrast, but their dependence on the orientation of microstructure with respect to the applied magnetic field, B0 , is often neglected. The aim of this work was to combine the fibre orientation information retrieved from the DWI acquisition and the sensitivity to microstructural information from quantitative relaxation parameters. The in vivo measured quantitative transverse relaxation maps (R2 and R2∗) were decomposed into their orientation-dependent and independent components, using the DWI fibre orientation information as prior knowledge. The analysis focused on major WM fibre bundles such as the forceps major (FMj), forceps minor (FMn), cingulum (CG) and corticospinal tracts (CST). The orientation-dependent R2 parameters, despite their small size (0-1.5 Hz), showed higher variability across different fibre populations, while those derived from R2∗, although larger (3.1-4.5 Hz), were mostly bundle-independent. With this article, we have, for the first time, attempted the in vivo characterization of the orientation-(in)dependent components of the transverse relaxation rates and demonstrated that the orientation of WM fibres influences both R2 and R2∗ contrasts.

Mots-clé
Algorithms, Anisotropy, Brain/anatomy & histology, Brain/diagnostic imaging, Diffusion Tensor Imaging/methods, Female, Humans, Image Interpretation, Computer-Assisted/methods, Magnetic Fields, Male, Reproducibility of Results, Scattering, Radiation, Sensitivity and Specificity, White Matter/anatomy & histology, White Matter/diagnostic imaging, Young Adult, R2, R∗2, fibre orientation, white matter
Pubmed
Web of science
Création de la notice
30/11/2016 21:55
Dernière modification de la notice
20/08/2019 12:27
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