Membrane potential dynamics of neocortical projection neurons driving target-specific signals.

Détails

ID Serval
serval:BIB_05249F75547A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Membrane potential dynamics of neocortical projection neurons driving target-specific signals.
Périodique
Neuron
Auteur(s)
Yamashita T., Pala A., Pedrido L., Kremer Y., Welker E., Petersen C.C.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
80
Numéro
6
Pages
1477-1490
Langue
anglais
Résumé
Primary sensory cortex discriminates incoming sensory information and generates multiple processing streams toward other cortical areas. However, the underlying cellular mechanisms remain unknown. Here, by making whole-cell recordings in primary somatosensory barrel cortex (S1) of behaving mice, we show that S1 neurons projecting to primary motor cortex (M1) and those projecting to secondary somatosensory cortex (S2) have distinct intrinsic membrane properties and exhibit markedly different membrane potential dynamics during behavior. Passive tactile stimulation evoked faster and larger postsynaptic potentials (PSPs) in M1-projecting neurons, rapidly driving phasic action potential firing, well-suited for stimulus detection. Repetitive active touch evoked strongly depressing PSPs and only transient firing in M1-projecting neurons. In contrast, PSP summation allowed S2-projecting neurons to robustly signal sensory information accumulated during repetitive touch, useful for encoding object features. Thus, target-specific transformation of sensory-evoked synaptic potentials by S1 projection neurons generates functionally distinct output signals for sensorimotor coordination and sensory perception.
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/01/2014 9:49
Dernière modification de la notice
20/08/2019 13:26
Données d'usage