Renal response to the angiotensin II receptor subtype 1 antagonist irbesartan versus enalapril in hypertensive patients.

Détails

ID Serval
serval:BIB_04C6DC549FBA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Renal response to the angiotensin II receptor subtype 1 antagonist irbesartan versus enalapril in hypertensive patients.
Périodique
Journal of hypertension
Auteur⸱e⸱s
Pechère-Bertschi A., Nussberger J., Decosterd L., Armagnac C., Sissmann J., Bouroudian M., Brunner H.R., Burnier M.
ISSN
0263-6352
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
16
Numéro
3
Pages
385-93
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
OBJECTIVE: To compare the acute and sustained renal hemodynamic effects on hypertensive patients of 100 mg irbesartan and 20 mg enalapril each once daily. PATIENTS: Twenty patients (aged 35-70 years) with uncomplicated, mild-to-moderate essential hypertension and normal serum creatinine levels completed this study. STUDY DESIGN: After random allocation to treatment (n=10 per group), administration schedule (morning or evening) was determined by further random allocation, with crossover of schedules after 6 weeks' therapy. Treatment and administration assignments were double-blind. Twenty-four-hour ambulatory blood pressure was monitored before and after 6 and 12 weeks of therapy. Renal hemodynamics were determined on the first day of drug administration and 12 and 24 h after the last dose during chronic treatment. RESULTS: Administration of each antihypertensive agent induced a renal vasodilatation with no significant change in glomerular filtration rate. However, the time course appeared to differ: irbesartan had no significant acute effect 4 h after the first dose, but during chronic administration a renal vasodilatory response was found 12 and 24 h after the dose; enalapril was effective acutely and 12 h after administration, but no residual effect was found 24 h after the dose. Both antihypertensive agents lowered mean ambulatory blood pressure effectively, with no significant difference between treatments or between administration schedules (morning versus evening). CONCLUSIONS: Irbesartan and enalapril have comparable effects on blood pressure and renal hemodynamics in hypertensive patients with normal renal functioning. However, the time profiles of the renal effects appear to differ, which might be important for long-term renoprotective effects.
Mots-clé
Adult, Aged, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Biphenyl Compounds, Blood Pressure, Cross-Over Studies, Double-Blind Method, Drug Administration Schedule, Enalapril, Female, Humans, Hypertension, Male, Middle Aged, Receptor, Angiotensin, Type 1, Receptor, Angiotensin, Type 2, Receptors, Angiotensin, Renal Circulation, Renin-Angiotensin System, Tetrazoles, Time Factors, Vasodilation
Pubmed
Web of science
Création de la notice
05/03/2008 16:41
Dernière modification de la notice
20/08/2019 12:26
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