Effet du facteur natriuretique auriculaire sur l'hematocrite de patients en hemodialyse chronique. [Effect of atrial natriuretic factor on the hematocrit of patients in chronic hemodialysis]

Détails

ID Serval
serval:BIB_0488CA2C7172
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effet du facteur natriuretique auriculaire sur l'hematocrite de patients en hemodialyse chronique. [Effect of atrial natriuretic factor on the hematocrit of patients in chronic hemodialysis]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur⸱e⸱s
Burnier  M., Porchet  M., Waeber  B., Wauters  J. P., Brunner  H. R.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
12/1987
Volume
117
Numéro
49
Pages
1953-6
Notes
English Abstract
Journal Article --- Old month value: Dec 5
Résumé
A synthetic atrial natriuretic peptide (ANF) has been administered to 7 patients with chronic renal failure to evaluate the role of ANF in the regulation of blood volume. ANF (2 micrograms/min) was infused for 60 minutes before hemodialysis and blood pressure, heart rate, plasma proteins and hematocrit were measured at regular intervals. Although a slight decrease in blood pressure occurred during ANF infusion, no significant changes in hematocrit and plasma proteins were observed. These results suggest that administration of exogenous ANF does not modify the volume distribution in patients with chronic renal failure. ANF's lack of effect is perhaps due to the chronic hypervolemia and the high plasma levels of endogenous ANF commonly found in these patients.
Mots-clé
Aged Atrial Natriuretic Factor/*pharmacology Blood Pressure/drug effects Blood Proteins/analysis Blood Volume Female Heart Rate/drug effects *Hematocrit Humans Kidney Failure, Chronic/*blood/physiopathology/therapy Male Middle Aged *Renal Dialysis
Pubmed
Web of science
Création de la notice
25/01/2008 12:55
Dernière modification de la notice
20/08/2019 12:26
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