On phagocytes and macular degeneration.

Détails

ID Serval
serval:BIB_040E29C2A332
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
On phagocytes and macular degeneration.
Périodique
Progress in retinal and eye research
Auteur⸱e⸱s
Guillonneau X., Eandi C.M., Paques M., Sahel J.A., Sapieha P., Sennlaub F.
ISSN
1873-1635 (Electronic)
ISSN-L
1350-9462
Statut éditorial
Publié
Date de publication
11/2017
Peer-reviewed
Oui
Volume
61
Pages
98-128
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumulation of mononuclear phagocytes (MP). We here discuss the origin and nature of subretinal MPs, the mechanisms that lead to their accumulation, the inflammatory mediators they produce as well as the consequences of their chronic presence on photoreceptors, retinal pigment epithelium and choroid. Recent advances highlight how both genetic and environmental risk factors directly promote subretinal inflammation and tip the balance from a beneficial inflammation that helps control debris accumulation to detrimental chronic inflammation and destructive late AMD. Finally, we discuss how changes in life style or pharmacological intervention can help to break the vicious cycle of inflammation and degeneration, restore the immunosuppressive properties of the subretinal space, and reestablish homeostasis.
Mots-clé
Choroid/metabolism, Choroid/pathology, Humans, Life Style, Macular Degeneration/etiology, Macular Degeneration/immunology, Macular Degeneration/physiopathology, Macular Edema/metabolism, Macular Edema/pathology, Phagocytes/immunology, Phagocytes/physiology, Photoreceptor Cells/metabolism, Photoreceptor Cells/pathology, Retinal Pigment Epithelium/metabolism, Retinal Pigment Epithelium/pathology
Pubmed
Web of science
Création de la notice
12/03/2021 18:28
Dernière modification de la notice
26/03/2021 6:35
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