Protection of axotomized ganglion cells by salicylic acid

Détails

ID Serval
serval:BIB_03FDEDE728E2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Protection of axotomized ganglion cells by salicylic acid
Périodique
Brain Research
Auteur(s)
Castagné V., Barnéoud P., Clarke P.G.H.
ISSN
0006-8993
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
840
Numéro
1-2
Pages
162-166
Langue
anglais
Résumé
Neuronal survival is influenced by the redox environment, and it has been shown that antioxidants protect developing neurons from the effects of axotomy. Here, we show that the intraocular injection of salicylic acid (SA) reduces the number of dying axotomized ganglion cells in the chick embryo. The antioxidant properties of SA are probably responsible for its protective effects, whose U-shaped dose-dependency matches that of several other antioxidants. We conclude that SA protects axotomized neurons by maintaining the redox status near an optimal set-point.
Mots-clé
Neuronal death, Antioxidant, Salicylic acid, Redox status, Chick embryo, Retina
Web of science
Création de la notice
20/01/2008 18:49
Dernière modification de la notice
20/08/2019 13:25
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