Testis morphology in patients with idiopathic hypogonadotropic hypogonadism.

Détails

ID Serval
serval:BIB_03F8F4D6308C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Testis morphology in patients with idiopathic hypogonadotropic hypogonadism.
Périodique
Human Reproduction
Auteur⸱e⸱s
Kumar P.A., Pitteloud N., Andrews P.A., Dwyer A., Hayes F., Crowley W.F., Dym M.
ISSN
0268-1161 (Print)
ISSN-L
0268-1161
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
21
Numéro
4
Pages
1033-1040
Langue
anglais
Notes
Publication types: Journal Article ; Research Support,
Résumé
BACKGROUND: Adult patients with idiopathic hypogonadotropic hypogonadism (IHH) typically present with absent puberty and therefore have prepubertal testes. IHH is recognized as one of the few curable causes of male infertility and is often effectively treated with either gonadotropins or pulsatile GnRH therapy. The objective of this study was to determine the structure of the testis prior to initiation of treatment.
METHODS AND RESULTS: Eight adult IHH patients with prepubertal testes (<4 ml), with no previous gonadotropin therapy and with no history of cryptorchidism underwent open bilateral testicular biopsy prior to the initiation of hormonal treatment. The testes of all patients showed seminiferous cords separated by interstitium composed of blood vessels, connective tissue cells and collagen fibres but typical adult Leydig cells were absent. The cords contained only Sertoli cells and early type A spermatogonia. The spermatogonia mostly resided in the centre of the cords and were often large, typical of gonocytes. Sertoli cells appeared immature with ovoid nuclei devoid of infoldings and cytoplasm that lacked polarity. Tight junctional complexes commonly found connecting adult Sertoli cells were lacking.
CONCLUSIONS: These results demonstrate that the immature testes from patients with the severe form of IHH possess early spermatogonia that could possibly reinitiate spermatogenesis with appropriate hormone stimulation. Therefore, the immature testis of this IHH subset resembles those of prepubertal boys and may provide important biologic and genetic insights into testicular development.
Mots-clé
Adult, Biopsy, Cohort Studies, Humans, Hypogonadism/pathology, Male, Testis/pathology, Testis/ultrastructure
Pubmed
Open Access
Oui
Création de la notice
03/12/2014 15:39
Dernière modification de la notice
20/08/2019 12:25
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