Harmonization of immune biomarker assays for clinical studies.

Détails

ID Serval
serval:BIB_03DCFBBD2035
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
Harmonization of immune biomarker assays for clinical studies.
Périodique
Science Translational Medicine
Auteur⸱e⸱s
van der Burg S.H., Kalos M., Gouttefangeas C., Janetzki S., Ottensmeier C., Welters M.J., Romero P., Britten C.M., Hoos A.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Statut éditorial
Publié
Date de publication
2011
Volume
3
Numéro
108
Pages
108ps44
Langue
anglais
Résumé
Assays that measure a patient's immune response play an increasingly important role in the development of immunotherapies. The inherent complexity of these assays and independent protocol development between laboratories result in high data variability and poor reproducibility. Quality control through harmonization--based on integration of laboratory-specific protocols with standard operating procedures and assay performance benchmarks--is one way to overcome these limitations. Harmonization guidelines can be widely implemented to address assay performance variables. This process enables objective interpretation and comparison of data across clinical trial sites and also facilitates the identification of relevant immune biomarkers, guiding the development of new therapies.
Pubmed
Web of science
Création de la notice
16/02/2012 15:19
Dernière modification de la notice
20/08/2019 12:25
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