Mathematical analysis of competition between sensory ganglion cells for neurotrophic factor in the skin.

Détails

ID Serval
serval:BIB_03B61A8EF78F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mathematical analysis of competition between sensory ganglion cells for neurotrophic factor in the skin.
Périodique
Mathematical Biosciences
Auteur⸱e⸱s
Kohli R., Gabriel J.P., Clarke P.G.H.
ISSN
0025-5564[print], 0025-5564[linking]
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
191
Numéro
2
Pages
207-225
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
A model is presented of competition between sensory axons for trophic molecules (e.g. a neurotrophin such as NGF), produced in a region of skin small enough to permit their free diffusion throughout it; e.g., a touch dome, or a vibrissal follicle hair sinus. The variables specified are the number of high affinity trophic factor receptors per axon terminal and the concentration of trophic factor in the extracellular space. Previous models of this class predicted the loss of all the axons innervating the region except the one requiring least trophic factor for its maintenance, even with high rates of trophic factor production. In the present model, we have imposed upper limits to axonal growth, thereby introducing new equilibria, and we show by a global analysis using LaSalle's theorem, and also by local analysis, that several axons can then coexist if the rate of production of trophic molecules is sufficiently high.
Mots-clé
Axons/metabolism, Axons/physiology, Models, Neurological, Nerve Growth Factor/metabolism, Nerve Growth Factor/physiology, Neurons, Afferent/metabolism, Neurons, Afferent/physiology, Receptors, Nerve Growth Factor/metabolism, Receptors, Nerve Growth Factor/physiology, Skin/innervation, Skin/metabolism
Pubmed
Web of science
Création de la notice
20/01/2008 18:49
Dernière modification de la notice
20/08/2019 13:25
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