Amisulpride poisoning: a report on two cases.

Détails

ID Serval
serval:BIB_039513D1C22C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Amisulpride poisoning: a report on two cases.
Périodique
Human and Experimental Toxicology
Auteur⸱e⸱s
Tracqui A., Mutter-Schmidt C., Kintz P., Berton C., Mangin P.
ISSN
0960-3271[print], 0960-3271[linking]
Statut éditorial
Publié
Date de publication
1995
Volume
14
Numéro
3
Pages
294-298
Langue
anglais
Résumé
The first two observations of human poisoning involving the recently developed neuroleptic amisulpride are described. In both cases drug determination was performed using reversed-phase HPLC coupled with diode array detection. Case 1 was a nonfatal overdosage in which the ingestion of 3.0 g amisulpride induced an attack of seizures, then light coma with agitation, hyperthermia, mydriasis, minimal extrapyramidal features, tachycardia and slight prolongation of the QT interval; the blood concentration of amisulpride was 9.63 micrograms ml-1. Case 2 was a fatality attributed to amisulpride in which the measured blood concentration was 41.70 micrograms ml-1. Our results are discussed in the light of data previously reported on the toxicity of substituted benzamides.
Mots-clé
Adult, Antipsychotic Agents/analysis, Antipsychotic Agents/poisoning, Chromatography, High Pressure Liquid, Female, Humans, Male, Sulpiride/analogs & derivatives, Sulpiride/analysis
Pubmed
Création de la notice
19/10/2010 15:34
Dernière modification de la notice
20/08/2019 12:25
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