Nonstereotyped responding in positive schizotypy after a single dose of levodopa

Détails

ID Serval
serval:BIB_035A3AD61FC6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Nonstereotyped responding in positive schizotypy after a single dose of levodopa
Périodique
Neuropsychopharmacology
Auteur(s)
Mohr C., Landis T., Sandor P.S., Fathi M., Brugger P.
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
29
Numéro
9
Pages
1741-1751
Langue
anglais
Notes
0893-133X (Print)
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Résumé
Stereotyped behavior and left-sided orientation biases, associated with the dopamine (DA) system, were observed in populations of the schizophrenia spectrum disorders. We investigated whether heightened DA concentrations influence both side biases and stereotyped responding in a visuo-motor computer task, in which 90, 180, and 270 degrees rotated objects had to be brought into a target position. To account for the role of the schizophrenia spectrum, task performance was also analyzed as a function of healthy participants' high or low magical ideation (MI), a positive schizotypal feature. The first 36 participants (20 women) remained substance free. In a second sample, 20 men received levodopa and 20 men a placebo in a double-blind procedure. Results showed that high MI scorers responded more stereotyped than low MI scorers, without being specifically biased towards the left side. Rotation preferences toward one or the other side made high MI scorers less flexible for objects efficiently to be rotated into the opposite direction. This inflexibility may reflect impaired left hemisphere functioning. Unexpectedly, in the levodopa group, high MI scorers performed superior to low MI scorers. Since DA actions appear to follow an inverted U-shape function, the 'low' performing high MI scorers profited from the enhanced DA availability. Our observation in the levodopa group points to a dissociation between schizotypy and schizophrenia: while cognitive improvement in schizophrenia can occur after treatment with atypical neuroleptic agents, in our positive schizotypal participants a DA agonist resulted in improved task performance. This dissociation may point to protective neurochemical mechanisms preventing healthy schizotypes from developing full-blown psychotic symptoms.
Mots-clé
Adult Behavior/*drug effects Double-Blind Method Female Functional Laterality/physiology Humans Imagination/drug effects Levodopa/*pharmacology Magic/psychology Male Psychomotor Performance/physiology Rotation *Schizophrenic Psychology Stereotyped Behavior/*drug effects
Open Access
Oui
Création de la notice
17/01/2011 19:07
Dernière modification de la notice
20/08/2019 12:25
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