The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Détails

ID Serval
serval:BIB_02F3067BAE73
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Périodique
Nature Reviews. Cancer
Auteur(s)
Radtke  F., Raj  K.
ISSN
1474-175X (Print)
Statut éditorial
Publié
Date de publication
10/2003
Volume
3
Numéro
10
Pages
756-67
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review --- Old month value: Oct
Résumé
Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.
Mots-clé
Genes, Tumor Suppressor/*physiology Humans Membrane Proteins/genetics/*physiology Neoplasms/genetics/*physiopathology Oncogenes/*physiology Receptors, Notch Signal Transduction/genetics/physiology Trans-Activators/genetics/*physiology
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 12:25
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