Reciprocal changes in vasoactive hormones in the rat myocardial infarction model of heart failure.

Détails

ID Serval
serval:BIB_02C95388F44B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Reciprocal changes in vasoactive hormones in the rat myocardial infarction model of heart failure.
Périodique
Journal of cardiac failure
Auteur⸱e⸱s
Zelis R., Nussberger J., Niederberger M., Zelis G.A., Genton C., Waeber B., Brunner H.R.
ISSN
1071-9164
Statut éditorial
Publié
Date de publication
10/1994
Peer-reviewed
Oui
Volume
1
Numéro
1
Pages
63-69
Langue
anglais
Résumé
The purpose of this study was to determine (1) if there is a relationship between the changes in the plasma levels of atrial natriuretic peptide (ANP) and plasma renin activity (PRA) as rats compensated from 3 days to 6 weeks after coronary ligation and (2) if these changes are related to myocardial infarction (MI) size. Arterial blood was drawn twice from 34 conscious rats (control, n = 10; small MI, n = 10; large MI, n = 14). Histologic MI size correlated better with ANP 3 days (r = .72, P < .001) than with ANP 6 weeks after MI (r = .39, P = .021). The reverse was true for an electrocardiographic index of MI size that used the sum of the Q waves minus the sum of the R waves in leads I, aVL, and V5. Atrial natriuretic peptide at 3 days was increased in both MI groups and was highest in the large MI group (control, 25.6; small MI, 41.0; large MI, 58.6 pM). Atrial natriuretic peptide decreased significantly from 3 days to 6 weeks in the large MI group and normalized in the small MI group (control, 25.0; small MI, 26.4; large MI, 44.4 pM). Plasma renin activity was not elevated at either time. However, the change in ANP from 3 days to 6 weeks in the MI rats was negatively related to the change in PRA (r = .48, P = .016). Atrial natriuretic peptide levels early after MI may be a good predictor of infarct size. The pattern of ANP and PRA changing in opposite directions over time suggest a counterregulatory link between these two systems.
Mots-clé
Animals, Atrial Natriuretic Factor, Cardiac Volume, Disease Models, Animal, Heart Failure, Male, Myocardial Infarction, Rats, Rats, Wistar, Renin
Pubmed
Création de la notice
05/03/2008 16:41
Dernière modification de la notice
20/08/2019 12:24
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