Gliotransmitters travel in time and space.

Détails

Ressource 1Télécharger: BIB_028C9626FD9E.P001.pdf (763.64 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_028C9626FD9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gliotransmitters travel in time and space.
Périodique
Neuron
Auteur(s)
Araque A., Carmignoto G., Haydon P.G., Oliet S.H., Robitaille R., Volterra A.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
81
Numéro
4
Pages
728-739
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks, and ultimately behavior. In this Perspective, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons.
Mots-clé
Animals, Astrocytes/physiology, Cell Communication/physiology, Humans, Neuronal Plasticity/physiology, Neurons/physiology, Synapses/metabolism, Synaptic Transmission/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/10/2016 15:32
Dernière modification de la notice
20/08/2019 13:24
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