Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein

Détails

ID Serval
serval:BIB_026DC15509D1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein
Périodique
Circulation Research
Auteur⸱e⸱s
Yang  Z. H., von Segesser  L., Bauer  E., Stulz  P., Turina  M., Luscher  T. F.
ISSN
0009-7330
Statut éditorial
Publié
Date de publication
01/1991
Peer-reviewed
Oui
Volume
68
Numéro
1
Pages
52-60
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
The endothelium releases substances controlling vascular tone and platelet function. We investigated mediators of endothelium-dependent responses in human internal mammary arteries and saphenous veins. The inhibitor of nitric oxide formation, NG-monomethyl L-arginine, enhanced the sensitivity to norepinephrine (fivefold) and evoked more pronounced endothelium-dependent contractions in internal mammary arteries (19 +/- 6% of 100 mM KCl) than in saphenous veins (2 +/- 1%; p less than 0.005). In internal mammary arteries, NG-monomethyl L-arginine, but not indomethacin, markedly reduced endothelium-dependent relaxations to acetylcholine (from 95 +/- 2% to 39 +/- 7%; p less than 0.005) and prevented those to histamine (78 +/- 6% to 4 +/- 3%; p less than 0.005). In saphenous veins, endothelium-dependent relaxations to acetylcholine were weak (24 +/- 11%), while nitric oxide caused comparable relaxations (85 +/- 3%) as in internal mammary arteries (80 +/- 5%; NS). NG-Monomethyl L-arginine prevented the relaxations to acetylcholine and unmasked endothelium-dependent contractions (30 +/- 10%). Indomethacin and the thromboxane synthetase inhibitor CGS-13080 augmented relaxations of saphenous veins to acetylcholine from 24 +/- 11% to 46 +/- 9% (p less than 0.05). Histamine-evoked contractions were converted to endothelium-dependent relaxations by indomethacin and the thromboxane A2/endoperoxide receptor antagonist SQ-30741 (38 +/- 3% and 40 +/- 6%; p less than 0.05) but not CGS-13080. Thus, 1) nitric oxide mediates endothelium-dependent relaxations in human arteries and veins; 2) internal mammary arteries release more nitric oxide than do saphenous veins, and 3) in saphenous veins, the effects of nitric oxide are reduced by endothelium-derived contracting factors originating from the cyclooxygenase pathway.
Mots-clé
Acetylcholine/metabolism Arginine/*metabolism Endothelium, Vascular/*metabolism Histamine Release Humans Mammary Arteries/drug effects/*metabolism Nitric Oxide/metabolism/pharmacology Norepinephrine/pharmacology Prostaglandin-Endoperoxide Synthases/*metabolism Saphenous Vein/drug effects/*metabolism Vasoconstriction Vasodilation
Pubmed
Web of science
Création de la notice
14/02/2008 14:15
Dernière modification de la notice
20/08/2019 12:24
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