Resting metabolic rate and protein turnover in apparently healthy elderly Gambian men.

Détails

ID Serval
serval:BIB_01B4183B72BF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Resting metabolic rate and protein turnover in apparently healthy elderly Gambian men.
Périodique
American Journal of Physiology. Endocrinology and Metabolism
Auteur(s)
Benedek C., Berclaz P.Y., Jéquier E., Schutz Y.
ISSN
0193-1849 (Print)
ISSN-L
0002-9513
Statut éditorial
Publié
Date de publication
1995
Volume
268
Numéro
6 Pt 1
Pages
E1083-E1088
Langue
anglais
Résumé
Body composition, resting energy expenditure (REE), and whole body protein metabolism were studied in 26 young and 28 elderly Gambian men matched for body mass index during the dry season in a rural village in The Gambia. REE was measured by indirect calorimetry (hood system) in the fasting state and after five successive meals. Rates of whole body nitrogen flux, protein synthesis, and protein breakdown were determined in the fed state from the level of isotopic enrichment of urinary ammonia over a period of 12 h after a single oral dose of [15N]glycine. Expressed in absolute value, REE was significantly lower in the elderly compared with the young group (3.21 +/- 0.07 vs. 4.04 +/- 0.07 kJ/min, P < 0.001) and when adjusted to body weight (3.29 +/- 0.05 vs. 3.96 +/- 0.05 kJ/min, P < 0.0001) and fat-free mass (FFM; 3.38 +/- 0.01 vs. 3.87 +/- 0.01 kJ/min, P < 0.0001). The rate of protein synthesis averaged 207 +/- 13 g protein/day in the elderly and 230 +/- 13 g protein/day in the young group, whereas protein breakdown averaged 184 +/- 13 g protein/day in the elderly and 203 +/- 13 g protein/day in the young group (nonsignificant). When values were adjusted for body weight or FFM, they did not reveal any difference between the two groups. It is concluded that the reduced REE adjusted for body composition observed in elderly Gambian men is not explained by a decrease in protein turnover.
Mots-clé
Adult, Aged, Aged, 80 and over, Aging/metabolism, Basal Metabolism, Body Composition, Energy Metabolism, Gambia, Humans, Male, Middle Aged, Proteins/metabolism, Reference Values
Pubmed
Web of science
Création de la notice
21/01/2008 14:10
Dernière modification de la notice
20/08/2019 13:23
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