Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.

Détails

Ressource 1Télécharger: s41467-020-16915-0.pdf (2013.52 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_0196B82A0620
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.
Périodique
Nature communications
Auteur⸱e⸱s
Hubbard J., Gent T.C., Hoekstra M.M.B., Emmenegger Y., Mongrain V., Landolt H.P., Adamantidis A.R., Franken P.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
19/06/2020
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
3130
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) sleep (NREMS) EEG delta (δ-)power are widely used as proxy for a sleep homeostatic process. Here, we noted frequency increases in δ-waves in sleep-deprived mice, prompting us to re-evaluate how slow-wave characteristics relate to prior sleep-wake history. We identified two classes of δ-waves; one responding to sleep deprivation with high initial power and fast, discontinuous decay during recovery sleep (δ2) and another unrelated to time-spent-awake with slow, linear decay (δ1). Reanalysis of previously published datasets demonstrates that δ-band heterogeneity after sleep deprivation is also present in human subjects. Similar to sleep deprivation, silencing of centromedial thalamus neurons boosted subsequent δ2-waves, specifically. δ2-dynamics paralleled that of temperature, muscle tone, heart rate, and neuronal ON-/OFF-state lengths, all reverting to characteristic NREMS levels within the first recovery hour. Thus, prolonged waking seems to necessitate a physiological recalibration before typical NREMS can be reinstated.
Pubmed
Open Access
Oui
APC
4717 EUR
Financement(s)
Université de Lausanne
Fonds national suisse / Projets / 31003A_146694
Fonds national suisse / Projets / CRSII3_136201
Fondation pour l'Université de Lausanne
Fonds national suisse / Communication scientifique / CRAC-3_198878
Création de la notice
06/07/2020 12:31
Dernière modification de la notice
20/01/2021 7:08
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