Case Report: SARS-CoV-2 as an unexpected causal agent of predominant febrile hepatitis.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_0194C4870252
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Case Report: SARS-CoV-2 as an unexpected causal agent of predominant febrile hepatitis.
Périodique
F1000Research
ISSN
2046-1402 (Electronic)
ISSN-L
2046-1402
Statut éditorial
Publié
Date de publication
2021
Peer-reviewed
Oui
Volume
10
Pages
400
Langue
anglais
Notes
Publication types: Case Reports
Publication Status: epublish
Publication Status: epublish
Résumé
Background: Respiratory symptoms and pneumonia are the predominant features of Coronavirus disease 2019 (COVID-19) due to emerging SARS-CoV-2 virus, but extrapulmonary manifestations are also observed. For instance, some degree of liver injury has been described among patients requiring hospital admission for severe COVID-19. However, acute febrile hepatitis as an initial or predominant manifestation of COVID-19 has been rarely reported. Case presentation: A 34-year-old man without underlying medical conditions presented with fever of unknown origin for two weeks in the absence of respiratory symptoms or other complaints. Laboratory testing revealed isolated acute hepatitis, for which an extensive microbiological work-up did not reveal identification of the causal agent. PCR testing for SARS-CoV-2 on a nasopharyngeal swab was negative on two occasions and initial serology for SARS-CoV-2 (at 15 days from symptoms onset) was also negative. However, repeated SARS-CoV-2 serological testing at 30 days demonstrated seroconversion leading to the diagnosis of COVID-19-related hepatitis. The patient's condition progressively improved, while transaminases steadily declined and eventually returned back to normal within 30 days. Conclusions: We describe here a unique case of SARS-CoV-2 isolated febrile hepatitis in a young and previously healthy man, which was diagnosed by demonstration of seroconversion, while PCR screening was negative. This case report highlights the role of repeated serological testing for the diagnosis of extrapulmonary manifestations of COVID-19.
Mots-clé
Adult, COVID-19, Fever/etiology, Hepatitis/diagnosis, Humans, Male, Polymerase Chain Reaction, SARS-CoV-2, hepatology, liver, serology
Pubmed
Open Access
Oui
Création de la notice
15/12/2021 16:57
Dernière modification de la notice
03/02/2022 8:08