Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.

Détails

Ressource 1Télécharger: fimmu-12-695150.pdf (5222.45 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_016349425533
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Périodique
Frontiers in immunology
Auteur(s)
Yakkala C., Dagher J., Sempoux C., Chiang C.L., Denys A., Kandalaft L.E., Koppolu B., Duran R.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
03/06/2021
Peer-reviewed
Oui
Volume
12
Pages
695150
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The emergence of ablative therapies has revolutionized the treatment of inoperable solid tumors. Cryoablation stands out for its uniqueness of operation based on hypothermia, and for its ability to unleash the native tumor antigens, resulting in the generation of anti-tumor immune responses. It is not clearly understood how alterations in the rate of freeze impact the immune response outcomes. In this study, we tested fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma. Tumor bearing mice treated with fast freeze protocol survived better than the ones treated with slow freeze protocol. Fast freeze resulted in a higher magnitude of CD4 <sup>+</sup> and CD8 <sup>+</sup> T-cell responses, and a significantly extended survival post re-challenge. Thus, fast freeze rate should be applied in any future studies employing cryoablation as an in vivo vaccination tool in conjunction with targeted immunotherapies.
Mots-clé
cryoablation, immune response, immunotherapy, melanoma, tumors
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/06/2021 15:54
Dernière modification de la notice
13/10/2021 6:08
Données d'usage