The extent of irradiation-induced long-term visceral organ damage depends on cranial/brain exposure

Détails

ID Serval
serval:BIB_012B2DAE5B56
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The extent of irradiation-induced long-term visceral organ damage depends on cranial/brain exposure
Périodique
PLoS One
Auteur⸱e⸱s
Boittin F. X., Denis J., Mayol J. F., Martigne P., Raffin F., Coulon D., Grenier N., Drouet M., Herodin F.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2015
Volume
10
Numéro
4
Pages
e0122900
Langue
anglais
Notes
Boittin, Francois-Xavier
Denis, Josiane
Mayol, Jean-Francois
Martigne, Patrick
Raffin, Florent
Coulon, David
Grenier, Nancy
Drouet, Michel
Herodin, Francis
eng
Research Support, Non-U.S. Gov't
2015/04/04
PLoS One. 2015 Apr 2;10(4):e0122900. doi: 10.1371/journal.pone.0122900. eCollection 2015.
Résumé
In case of high-dose radiation exposure, mechanisms controlling late visceral organ damage are still not completely understood and may involve the central nervous system. To investigate the influence of cranial/brain irradiation on late visceral organ damage in case of high-dose exposure, Wistar rats were irradiated at 12 Gy, with either the head and fore limbs or the two hind limbs protected behind a lead wall (head- and hind limbs-protected respectively), which allows long-term survival thanks to bone marrow protection. Although hind limbs- and head-protected irradiated rats exhibited similar hematopoietic and spleen reconstitution, a late body weight loss was observed in hind limbs-protected rats only. Histological analysis performed at this time revealed that late damages to liver, kidney and ileum were attenuated in rats with head exposed when compared to animals whose head was protected. Plasma measurements of inflammation biomarkers (haptoglobin and the chemokine CXCL1) suggest that the attenuated organ damage in hind limbs-protected rats may be in part related to reduced acute and chronic inflammation. Altogether our results demonstrate the influence of cranial/brain exposure in the onset of organ damage.
Mots-clé
Analysis of Variance, Animals, Brain/*radiation effects, Chemokine CXCL1/blood, Haptoglobins/metabolism, Hemibody Irradiation/*adverse effects, Histological Techniques, *Radiation Exposure, Rats, Rats, Wistar, Skull/*radiation effects, Viscera/*pathology/*radiation effects, Weight Loss/radiation effects
Pubmed
Création de la notice
02/05/2024 10:41
Dernière modification de la notice
28/05/2024 7:09
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