Cancers du sein hereditaires. [Hereditary breast cancers]

Détails

ID Serval
serval:BIB_011861356B35
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Cancers du sein hereditaires. [Hereditary breast cancers]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur⸱e⸱s
Perey  L., Schorderet  D. F.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
08/1996
Volume
85
Numéro
35
Pages
1035-9
Notes
English Abstract
Journal Article
Review --- Old month value: Aug 27
Résumé
Recently, genetic analyses in high risk families with several members suffering of breast and/or ovarian carcinoma led to the discovery of two genes, called BRCA1 and BRCA2, clearly responsible for hereditary predisposition of breast carcinoma. Another gene, p53, was also shown to be involved in hereditary predisposition of breast and other tumors in the setting of Li-Fraumeni syndrome. It is very important that women at risk could be seen by a specialized team for genetic counselling and explanation of advances and limits of molecular genetics. Such a team should be multidisciplinary in order to cover genetic, oncological, social, psychological and economical aspects of hereditary cancer predisposition. Prevention interventions and early detection methods are still investigational and definitely need to be performed in the setting of protocols in order to better evaluate their long term efficacy.
Mots-clé
Adult Aged Aged, 80 and over Breast Neoplasms/*genetics Breast Neoplasms, Male/genetics Female Genetic Counseling Heterozygote Detection Humans Li-Fraumeni Syndrome/genetics Male Middle Aged Oncogenes/genetics Patient Care Team Point Mutation Polymerase Chain Reaction
Pubmed
Création de la notice
28/01/2008 12:58
Dernière modification de la notice
20/08/2019 12:23
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