Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2

Détails

ID Serval
serval:BIB_00E79F571ED8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2
Périodique
International Journal of Cancer
Auteur⸱e⸱s
Ma  W., Germeau  C., Vigneron  N., Maernoudt  A. S., Morel  S., Boon  T., Coulie  P. G., Van den Eynde  B. J.
ISSN
0020-7136 (Print)
Statut éditorial
Publié
Date de publication
05/2004
Volume
109
Numéro
5
Pages
698-702
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 1
Résumé
We have identified 2 antigens recognized by several melanoma-specific cytolytic T lymphocyte clones isolated from a melanoma patient with a clinical history of tumor regression after immunotherapy. Both antigens are presented by HLA-A2 and encoded by gene MAGE-C2, a cancer-germline gene shown previously to be silent in normal somatic tissues and expressed in 40% of melanomas and in other tumor types. One antigen corresponds to peptide ALKDVEERV(336-344), whereas the other corresponds to peptide LLFGLALIEV(191-200). The CTL clones recognizing these 2 peptides also recognized allogeneic tumor cell lines expressing MAGE-C2 and HLA-A2. These 2 new peptides are the first known MAGE-C antigens and represent promising targets for cancer immunotherapy.
Mots-clé
Amino Acid Sequence Antigens, Neoplasm/*genetics DNA, Complementary/metabolism DNA, Neoplasm/metabolism HLA-A2 Antigen/*immunology Humans Lymphatic Metastasis Melanoma/*genetics/*immunology Molecular Sequence Data Neoplasm Proteins/*genetics Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 9:36
Dernière modification de la notice
20/08/2019 12:23
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