Cognitive impairment in late-onset depression. Limited to a decrement in information processing resources ?

Détails

ID Serval
serval:BIB_00E4636E7589
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cognitive impairment in late-onset depression. Limited to a decrement in information processing resources ?
Périodique
European Neurology
Auteur⸱e⸱s
Delaloye Christophe, Baudois S., Bilbao Fabienne de, Dubois Remund C., Hofer F., Lamon M., Ragno Paquier C., Weber Kerstin, Herrmann François R., Giardini Umberto, Giannakopoulos Panteleimon
ISSN
0014-3022
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
60
Numéro
3
Pages
149-154
Langue
anglais
Notes
SAPHIRID:70792
Résumé
BACKGROUND: While cognitive dysfunction in late-onset depression (LOD) is common, the nature and determinants of this impairment are heterogeneous. It has been suggested that neuropsychological decrements in LOD patients might result from a deficit in processing resources. In order to address this issue, we analyzed processing resources in LOD to see if their decrease explains higher-level cognition (episodic memory and naming capacity) deficits. METHODS: Measures of processing speed, working memory, inhibition, episodic memory and naming capacity were administered to 14 LOD inpatients and 14 controls. RESULTS: The LOD patients performed significantly worse than the controls in all domains except for inhibition. Hierarchical regression analyses showed that naming capacity impairment was totally mediated by processing speed and working memory, whereas episodic memory dysfunction was only partially mediated by working memory. CONCLUSION: The reduction in certain processing resources (working memory, processing speed) in late-onset depressed patients appears to mediate impairments in episodic memory and naming capacity. However, episodic memory impairment cannot only be explained by processing resource decrement in LOD patients, suggesting that a primary episodic memory dysfunction is present in this condition. 2008 S. Karger AG, Basel.
Pubmed
Web of science
Création de la notice
15/12/2008 12:10
Dernière modification de la notice
20/08/2019 12:23
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