Detection of amphetamines in fingernails: an alternative to hair analysis.

Détails

ID Serval
serval:BIB_00B06E2843A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Detection of amphetamines in fingernails: an alternative to hair analysis.
Périodique
Archives of Toxicology
Auteur⸱e⸱s
Cirimele V., Kintz P., Mangin P.
ISSN
0340-5761[print], 0340-5761[linking]
Statut éditorial
Publié
Date de publication
1995
Volume
70
Numéro
1
Pages
68-69
Langue
anglais
Résumé
After external decontamination, the extraction of amphetamine (AP), 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) from hair and fingernails was accomplished via hot alkaline hydrolysis (1 ml 1 N NaOH, 10 min at 95 degrees C) in the presence of deuterated internal standards, followed by a three-step extraction procedure. The target drugs were derivatized by propionylation and analyzed by GC/MS operated in the electronic impact mode. Results indicated that AP, MDA and MDMA were present in both hair and fingernails. Their concentrations, slightly higher in fingernails than in head hair, were 10.2 and 12.0 ng/mg for AP, 8.0 and 9.7 ng/mg for MDA and 53.4 and 60.2 ng/mg for MDMA in head hair and in fingernails, respectively.
Mots-clé
Adult, Amphetamines/toxicity, Hair/chemistry, Humans, Male, Nails/chemistry
Pubmed
Création de la notice
19/10/2010 15:40
Dernière modification de la notice
20/08/2019 12:23
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