Transepithelial transport and mucosal defence II: secretion of IgA

Détails

ID Serval
serval:BIB_00219E3E03D0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Transepithelial transport and mucosal defence II: secretion of IgA
Périodique
Trends in Cell Biology
Auteur(s)
Kraehenbuhl  J. P., Neutra  M. R.
ISSN
0962-8924 (Print)
Statut éditorial
Publié
Date de publication
06/1992
Volume
2
Numéro
6
Pages
170-4
Notes
Journal Article --- Old month value: Jun
Résumé
In this second article on mucosal defence and transepithelial transport, Jean-Pierre Kraehenbuhl and Marian Neutra discuss the part played by a special class of antibody, polymeric IgA, in the protection of mucosal surfaces lining the digestive, respiratory and genital tracts, and the implications for mucosal vaccines. Polymeric IgA crosslinks luminal antigens or pathogens, thus preventing their interaction with epithelial cells. Following stimulation by antigen in the organized mucosal lymphoid tissue, effector B lymphocytes enter the circulation and migrate to distant mucosal or glandular sites, where they differentiate into polymeric-IgA-producing plasma cells. These antibodies reach the environment by transport across the epithelial cells of mucosal and glandular tissues.
Pubmed
Création de la notice
25/01/2008 16:05
Dernière modification de la notice
20/08/2019 13:22
Données d'usage